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  Indian J Med Microbiol
 

Figure 4: Biodistribution data of control mouse with (gold nanoparticle) labeled nonspecific Gammaglobulin. Nanogold-labeled nonspecific antibody (Bharglob) biodistribution was performed for 120 h. It was observed that the gold-labeled antibody showed considerable activity in the stomach, liver, spleen, and other organs which could represent reticuloendothelial system localization. In all the studies, it was observed that reticuloendothelial system is the major site of accumulation of labeled compound using both specific- and nonspecific-labeled antibodies, thereby limiting the attainment of high tumor/nontumor ratios

Figure 4: Biodistribution data of control mouse with (gold nanoparticle) labeled nonspecific Gammaglobulin. Nanogold-labeled nonspecific antibody (Bharglob) biodistribution was performed for 120 h. It was observed that the gold-labeled antibody showed considerable activity in the stomach, liver, spleen, and other organs which could represent reticuloendothelial system localization. In all the studies, it was observed that reticuloendothelial system is the major site of accumulation of labeled compound using both specific- and nonspecific-labeled antibodies, thereby limiting the attainment of high tumor/nontumor ratios