Indian Journal of Nuclear Medicine

CASE REPORT
Year
: 2017  |  Volume : 32  |  Issue : 1  |  Page : 25--29

Hypothyroidism in mccune–albright syndrome and role of bone scan in management of fibrous dysplasia: An unusual case scenario with review of literature


Narvesh Kumar1, Subhash Chand Kheruka1, Rani Kunti R Singh2, Mudalsha Ravina1, Deepanksha Dutta1, Sanjay Gambhir1 
1 Department of Nuclear Medicine, SGPGIMS, Lucknow, Uttar Pradesh, India
2 Department of Radiodiagnosis, Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
Sanjay Gambhir
Department of Nuclear Medicine, SGPGIMS, Raebareli Road, Lucknow, Uttar Pradesh
India

The McCune–Albright syndrome (MAS) is a triad of café-au-lait skin pigmentation, precocious puberty (PP), and polyostotic fibrous dysplasia of bone (FD). In general, FD seems to be the most common component of MAS but very rarely precocious puberty can be found in association with café-au-lait skin pigmentation in the absence of FD (about 1% of the cases). Therefore, a more clinically relevant definition of MAS is fibrous dysplasia of bone (FD) and at least one of the typical hyperfunctioning endocrinopathy and/or café-au-lait spots, with almost any combination possible. Bone scan can be the modality of choice to look for bone disease burden of fibrous dysplasia in most patients of MAS and may change the management accordingly. Most of the cases of MAS reported worldwide are associated with hyperthyroidism, up to best of our knowledge on the basis of literature search in pubmed and Google; no case was reported with hypothyroidism. Herein, we report a 12-year-old girl diagnosed with MAS and associated hypothyroidism.We have also reviewed the MAS related literature.


How to cite this article:
Kumar N, Kheruka SC, Singh RR, Ravina M, Dutta D, Gambhir S. Hypothyroidism in mccune–albright syndrome and role of bone scan in management of fibrous dysplasia: An unusual case scenario with review of literature.Indian J Nucl Med 2017;32:25-29


How to cite this URL:
Kumar N, Kheruka SC, Singh RR, Ravina M, Dutta D, Gambhir S. Hypothyroidism in mccune–albright syndrome and role of bone scan in management of fibrous dysplasia: An unusual case scenario with review of literature. Indian J Nucl Med [serial online] 2017 [cited 2021 Apr 19 ];32:25-29
Available from: https://www.ijnm.in/article.asp?issn=0972-3919;year=2017;volume=32;issue=1;spage=25;epage=29;aulast=Kumar;type=0