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Year : 2021  |  Volume : 36  |  Issue : 1  |  Page : 92-94

Obstructive jaundice: An unusual presentation of neuroendocrine differentiation in prostatic adenocarcinoma


1 Division of PET/CT, Gemini Scans, Chennai, Tamil Nadu, India
2 Institute of Oncology, SRM Institute of Medical Sciences, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Sampath Santhosh
Division of PET/CT, Gemini Scans, Vadapalani, Chennai - 600 026, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnm.IJNM_127_20

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An elderly male on androgen deprivation therapy for prostatic adenocarcinoma presented with obstructive jaundice. Since biopsy from the head of the pancreas showed neuroendocrine carcinoma (NEC), he was diagnosed with second primary pancreatic NEC. Ga-68 DOTANOC positron emission tomography/computed tomography (PET/CT) done subsequently showed enlarged mildly DOTANOC-avid retroperitoneal nodes infiltrating the pancreas. These nodes were found to be progression of prostate-specific membrane antigen (PSMA) nonavid retroperitoneal nodes visualized in his Ga-68 PSMA PET/CT performed at another institution before 4 months, when there was no lesion in the pancreas. This observation revised the diagnosis from second primary pancreatic NEC to progression of neuroendocrine differentiation in preexisting prostatic adenocarcinoma.


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