| TECHNICAL NOTE |
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| Year : 2018 | Volume
: 33
| Issue : 4 | Page : 355-358 |
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Troubleshooting for F-18 fluorocholine synthesis: An institutional experience
Rakhee Vatsa1, Raman Kumar Joshi2, Jaya Shukla1, Bhagwant Rai Mittal1
1 Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh, Karnataka, India
2 Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neuroscience, Bengaluru, Karnataka, India
Correspondence Address:
Rakhee Vatsa
Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijnm.IJNM_85_18
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Choline is a natural substrate for phospholipid synthesis. F-18 labeled fluorocholine nowadays is routinely used for imaging brain tumors, parathyroid adenoma, and prostate cancer. It is synthesized through nucleophilic substitution reaction using dibromomethane and N, N-dimethylaminoethanol as primary and secondary precursors, respectively. However, sometimes, failures are encountered in F-18 fluorocholine production. Few problems and troubleshooting during synthesis are discussed here.
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