Indian Journal of Nuclear Medicine
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CASE REPORT
Year : 2017  |  Volume : 32  |  Issue : 4  |  Page : 343-344

Severe hypercalcemia related to silicone granulomas, as discovered by FDG-PET


Department of Radiology, Mayo Clinic, Jacksonville, Florida, USA

Correspondence Address:
Dana E Amiraian
Department of Radiology, Mayo Clinic, Jacksonville, Florida
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnm.IJNM_33_17

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Silicone injected for cosmetic purposes can provoke an inflammatory granulomatous response. In turn, silicone granulomas can lead to hypercalcemia, which is a rare, though potentially life-threatening condition. Hypercalcemia is a nonspecific laboratory finding with many potential etiologies. It may be difficult for clinicians to diagnose silicone-induced hypercalcemia, since the history of cosmetic silicone injections may not be elicited from the patient. Positron emission tomography using F-18-fluorodeoxyglucose (FDG-PET) can be used to evaluate patients with unexplained hypercalcemia as a means of searching for an occult malignancy or granulomatous process. FDG-PET findings may be the initial and perhaps only indication of silicone granulomas as the cause of hypercalcemia. Nuclear medicine physicians should have a low threshold for suggesting this diagnosis, particularly in the setting of unexplained hypercalcemia. This case report highlights the value of FDG-PET in diagnosing silicone granuloma-induced hypercalcemia.


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