|Year : 2017 | Volume
| Issue : 2 | Page : 148-149
Cerebral toxoplasmosis masquerading CNS lymphoma on FDG PET-CT in post renal transplant patient
Anirban Mukherjee1, Chandrasekhar Bal1, Madhavi Tripathi1, Chandan Jyoti Das2, Shamim Ahmed Shamim1
1 Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
2 Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India
|Date of Web Publication||16-Mar-2017|
Asst. Prof. Shamim Ahmed Shamim
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi
Source of Support: None, Conflict of Interest: None
| Abstract|| |
20 year old post renal transplant patient developed recurrent episodes of seizure. MRI revealed focal lesion in right parieto-occipital lobe with perilesional edema. FDG PET-CT revealed multiple hypermetabolic lesions in bilateral cerebral hemisphere. Subsequent biopsy from the lesion demonstrated bradyzoites of Toxoplasma gondii with inflammatory cells and thereby, a confirmatory diagnosis of cerebral toxoplasmosis was made. This case demonstrates the fact that increased FDG uptake in cerebral lesions in post transplant patient should be interpreted with caution and confirmed with histopathological correlation.
Keywords: FDG PET-CT, cerebral toxoplasmosis, post transplant lymphomatous disorder
|How to cite this article:|
Mukherjee A, Bal C, Tripathi M, Das CJ, Shamim SA. Cerebral toxoplasmosis masquerading CNS lymphoma on FDG PET-CT in post renal transplant patient. Indian J Nucl Med 2017;32:148-9
|How to cite this URL:|
Mukherjee A, Bal C, Tripathi M, Das CJ, Shamim SA. Cerebral toxoplasmosis masquerading CNS lymphoma on FDG PET-CT in post renal transplant patient. Indian J Nucl Med [serial online] 2017 [cited 2021 May 10];32:148-9. Available from: https://www.ijnm.in/text.asp?2017/32/2/148/202254
A 20 year old post renal transplant patient, who was subsequently kept on immunosuppressive therapy, experienced a single episode of seizure after two years of renal transplant. MRI was advised which revealed a focal lesion in the right parieto-occipital lobe (solid arrow) which was hyperintense on both T2 and T1 weighted images with significant perilesional edema [Figure 1]. A differential diagnosis of post transplant lymphoproliferative disorder (PTLD) vs CNS toxoplasmosis was made and patient was referred for 18F- Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG PET-CT) for further evaluation. 18F-FDG PET-CT revealed multiple hypermetabolic enhancing lesions involving left parietal lobe, left parasagittal location and right parieto-occipital lobe [Figure 2]. Maximum Standardised Uptake Value (SUVmax) of the lesion in left parasagittal location was 12.5. All the lesions demonstrated greater uptake than normal brain parenchyma. So, a possible diagnosis of PTLD was made. However, for further confirmation brain biopsy was performed from the right parieto-occipital lobe lesion which demonstrated bradyzoites of Toxoplasma gondii with inflammatory cells and thereby a confirmatory diagnosis of cerebral toxoplasmosis was made. The patient was given anti-toxoplasma therapy with pyrimethamine, sulfadiazine, and folinic acid in combination. Subsequent MRI revealed significant reduction in size of the lesion and perilesional edema [Figure 3].
|Figure 1: MRI revealed a focal lesion in the right parieto-occipital lobe which was hyperintense on both T2 and T1 weighted images with significant perilesional edema|
Click here to view
|Figure 2: 18F-FDG PET-CT revealed multiple hypermetabolic enhancing lesions involving left parietal lobe, left parasagittal location and right parieto-occipital lobe|
Click here to view
|Figure 3: Post treatment MRI revealed significant reduction in size of the lesion and perilesional edema|
Click here to view
Toxoplasma gondii is a protozoan parasite, which causes opportunistic infections in the immunocompromised, as in solid-organ transplant., PTLD is a serious complication of solid organ transplantation with incidence in renal transplant recipients of -1-4%. Central nervous system (CNS) lymphoma is a rare form of PTLD and is more common after renal transplantation. The distinction between primary CNS lymphoma and cerebral toxoplasmosis is important because of difference in the treatment. Cerebral toxoplasmosis can be treated with medication, whereas primary CNS lymphomas are usually treated with radiation therapy and corticosteroids. However, neither CT nor MRI scans can reliably distinguish CNS toxoplasmosis from lymphoma. Several authors reported the usefulness of FDG PET to differentiate cerebral toxoplasmosis from primary CNS lymphoma. Villringer et al. compared FDG uptake within the lesion with the uptake in a contralateral brain area. In all subjects with CNS toxoplasmosis, the FDG uptake ratio was significantly lower than the FDG ratio in patients with lymphoma. Hoffman et al. also reported significant difference between FDG uptake in lymphoma and cerebral toxoplasmosis. Westwood et al. also reported the utility of FDG PET-CT in differentiating CNS toxoplasmosis from PTLD. However, all the above mentioned studies were performed in the settings of HIV infection. Whether similar difference exists in the settings of solid organ transplant is a matter of debate. Furthermore, in contrast to the findings of the above mentioned studies, we have found significant higher uptake in the lesions of CNS toxoplasmosis in a post renal transplant patient. Therefore, increased FDG uptake of the cerebral lesion in patients with solid organ transplant should be interpreted with caution in differentiating CNS toxoplasmosis from PTLD and should be confirmed by histopathological evaluation.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest
| References|| |
Beraud G, Sandrine PF, Foltzer A, Abel S, Liautaud B, Smadja D, et al.
Cotrimoxazole for treatment of cerebral Toxoplasmosis: An observational cohort study during 1994-2006. Am J Trop Med Hyg 2009;80:583-7.
Derouin F, Pelloux H. Prevention of toxoplasmosis in transplant patients. Clin Microbiol Infect 2008;14:1089-101.
Selby R, Ramirez CB, Singh R, Kleopoulos I, Kusne S, Starzl TE, et al.
Brain abscess in solid organ transplant recipients receiving cyclosporine based immunosuppression. Arch Surg 1997;132:304-10.
Kim HW, Won KS, Choi BW, Zeon SK. Cerebral Toxoplasmosis in a Patient with AIDS on F-18 FDG PET/CT. Nucl Med Mol Imaging 2010;44:75-7.
Sathekge M, Goethals I, Maes A, van de Wiele C. Positron emission tomography in patients suffering from HIV-1 infection. Eur J Nucl Med Mol Imaging 2009;36:1176-84.
Villringer K, Jager H, Dichgans M, Ziegler S, Poppinger J. Herz M , et al.
Differential diagnosis of CNS lesions in aids patients by FDG-PET. J Comput Assist Tomogr 1995;19:532-6.
Hoffman JM, Waskin HA, Schifter T, Hanson MW, Gray L, Rosenfeld S, et al.
FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS. J Nucl Med 1993;34:567-75.
Westwood TD, Hogan C, Julyan PJ, Coutts G, Bonington S, Carrington B, et al.
Utility of FDG-PETCT and magnetic resonance spectroscopy in differentiating between cerebral lymphoma and non-malignant CNS lesions in HIV-infected patients. Eur J Radiol 2013;82:e374-9.
[Figure 1], [Figure 2], [Figure 3]