|Year : 2016 | Volume
| Issue : 4 | Page : 309-310
Tc-99m TRODAT uptake in an osteoid tumor of clivus
Sameer Taywade1, Madhavi Tripathi1, Vivek Tandon2, Chandan Jyoti Das3, Nishikant Avinash Damle1, Shamim Ahmed Shamim1, Parul Thukral1, Chandrasekhar Bal1
1 Department of Nuclear Medicine and PET/CT, All India Institute of Medical Sciences, New Delhi, India
2 Department of Neurosurgery, CN Centre, All India Institute of Medical Sciences, New Delhi, India
3 Department of Radiology, All India Institute of Medical Sciences, New Delhi, India
|Date of Web Publication||19-Sep-2016|
Department of Nuclear Medicine and PET/CT, All India Institute of Medical Sciences, New Delhi - 110 029
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Tc-99m TRODAT is cocaine analog and binds to the dopamine transporter in vivo. Tc-99m TRODAT single-photon emission computed tomography/computed tomography. (SPECT/CT) is useful for demonstrating presynaptic dopaminergic dysfunction in patients with Parkinsonism. However, few reports have shown extrastriatal uptake of Tc-99m TRODAT. We present the case of a 67-year-old male who underwent Tc-99m TRODAT SPECT/CT for evaluation of Parkinsonism. In addition to tracer binding in the striatum, tracer uptake was noted in an osteoid tumor of the clivus. Integrated SPECT/CT enabled precise localization and characterization of the extrastriatal site of tracer binding and emphasizes the importance of such coincidental findings.
Keywords: Osteoid tumor, Parkinson's disease, single-photon emission computed tomography/computed tomography, Tc-99m TRODAT
|How to cite this article:|
Taywade S, Tripathi M, Tandon V, Das CJ, Damle NA, Shamim SA, Thukral P, Bal C. Tc-99m TRODAT uptake in an osteoid tumor of clivus. Indian J Nucl Med 2016;31:309-10
|How to cite this URL:|
Taywade S, Tripathi M, Tandon V, Das CJ, Damle NA, Shamim SA, Thukral P, Bal C. Tc-99m TRODAT uptake in an osteoid tumor of clivus. Indian J Nucl Med [serial online] 2016 [cited 2022 May 21];31:309-10. Available from: https://www.ijnm.in/text.asp?2016/31/4/309/190805
A 67-year-old male patient complained of gait imbalance for the past 1 year. The treating neurologist referred him for ([2-[2-[3-(4-chlorophenyl)-8-methyl-8-azabicyclo [3, 2, 1]oct-2-yl] methyl](2-mercaptoethyl)-amino] ethyl] amino] ethanethiolato (3-)-N2, N2', S2, S2']oxo-[1R-(exo-exo)]) (Tc-99 m TRODAT) single-photon emission computed tomography/computed tomography (SPECT/CT). Axial fused SPECT/CT [Figure 1]a showed asymmetric tracer accumulation in the basal ganglia. The corresponding plain CT axial image [Figure 1]b showed an infarct in the right frontal white matter with no lesion in the basal ganglia. Axial fused SPECT/CT image at the level of pons showed increased radiotracer uptake in the clival region [Figure 1]c while corresponding axial plain CT image in the bone window showed a predominantly sclerotic lesion in the clivus [Figure 1]d. On taking a detailed history again, the patient revealed that he had undergone a magnetic resonance imaging 2 years back which had revealed the lesion which was considered as a benign osteoid tumor of the clivus and no active intervention was planned.
|Figure 1: Tc-99m TRODAT (a) axial fused single-photon emission computed tomography/computed tomography images showed asymmetric tracer accumulation in the basal ganglia. The corresponding computed tomography axial image (b) showed an infarct in the right frontal white matter with no lesion in the basal ganglia. Axial fused single-photon emission computed tomography/computed tomography image (c) at the level of pons showed increased radiotracer uptake in the clival region, while corresponding axial plain computed tomography image in bone window showed a predominantly sclerotic lesion in the clivus (d)|
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Dopamine transporter imaging has been widely used in movement disorders including Parkinson's disease.,, Tc-99m TRODAT, a cocaine derivative, is a neutral lipophilic complex that contains N-(alkylthiolate) tropane, aminobis (ethylthiolate) and a center core of Tc-99m. Although it has high specificity and affinity for dopamine transporter, few studies elucidated uptake in extrastriatal pathology.,,,,,,, Osteoid is composed of fibers (type-1 collagen) and ground substance (chondroitin sulfate and osteocalcin). TRODAT uptake in an osteoid lesion has not been described in the literature, and the mechanism of this localization needs consideration.
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