Indian Journal of Nuclear Medicine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 35  |  Issue : 2  |  Page : 105--109

Role of18F-flurodeoxyglucose positron-emission tomography/computed tomography in the evaluation of early response to neoadjuvant chemotherapy in patients with locally advanced triple-negative breast cancer


Bina Basnet1, Pankaj Goyal2, Vivek Mahawar1, Sneha Jatan Bothra2, Chaturbhuj Agrawal2, Bikash Bikram Thapa3, Vineet Talwar2, Parveen Jain2, Venkata Pradeep Babu Koyyala2, Varun Goel2, Ullas Batra2, Dinesh Chandra Doval2 
1 Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
2 Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
3 Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India

Correspondence Address:
Dr. Vivek Mahawar
Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi
India

Background: Response evaluation in locally advanced breast cancer is done through different methods ranging from clinical examination to magnetic resonance imaging, however evaluation with positron-emission tomography/computed tomography (PET/CT) in now being incorporated for the response evaluation. The aim of the present study is to correlate response to neoadjuvant chemotherapy (NACT) with PET/CT scan. Materials and Methods: The present study is a retrospective analysis of 30 locally advanced, triple-negative breast cancer patients. PET/CT scan was done pretreatment and post three and six cycles of NACT and was correlated with pathologic complete response (pCR). Responding disease was considered when there was at least a 50% reduction in the longest diameter. Results: The median pretreatment size of the breast lesion in CT scan was 3.9 ± 2.3 cm (2–12 cm) and maximum standardized uptake value (SUVmax) on PET/CT was 8.5 ± 5.5 (2.9–24). Among the responders, the median decrease in size of lesion was 3.2 ± 1.3 cm and median reduction in SUV of the tumor among was −8.1 ± 5.4 and was statistically significant when compared with nonresponders (P < 0.001). CT scan has 66% accuracy and PET has 82% accuracy at post three cycles NACT in predicting the pathological response. PET/CT had higher sensitivity and specificity when compared with CT findings alone in response evaluation. Conclusion: PET/CT scan can be considered as a sensitive tool for predicting pCRs and further larger trials are required to establish these findings.


How to cite this article:
Basnet B, Goyal P, Mahawar V, Bothra SJ, Agrawal C, Thapa BB, Talwar V, Jain P, Babu Koyyala VP, Goel V, Batra U, Doval DC. Role of18F-flurodeoxyglucose positron-emission tomography/computed tomography in the evaluation of early response to neoadjuvant chemotherapy in patients with locally advanced triple-negative breast cancer.Indian J Nucl Med 2020;35:105-109


How to cite this URL:
Basnet B, Goyal P, Mahawar V, Bothra SJ, Agrawal C, Thapa BB, Talwar V, Jain P, Babu Koyyala VP, Goel V, Batra U, Doval DC. Role of18F-flurodeoxyglucose positron-emission tomography/computed tomography in the evaluation of early response to neoadjuvant chemotherapy in patients with locally advanced triple-negative breast cancer. Indian J Nucl Med [serial online] 2020 [cited 2020 May 31 ];35:105-109
Available from: http://www.ijnm.in/article.asp?issn=0972-3919;year=2020;volume=35;issue=2;spage=105;epage=109;aulast=Basnet;type=0