Indian Journal of Nuclear Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 34  |  Issue : 3  |  Page : 188--193

Ga-68 DOTATATE positron emission tomography-computed tomography imaging in oncogenic osteomalacia: Experience from a Tertiary Level Hospital in South India


Junita Rachel John, Julie Hephzibah, Regi Oommen, Nylla Shanthly, David Mathew 
 Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Dr. Julie Hephzibah
Department of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu
India

Aim: Utility of Ga68 DOTATATE PETCT imaging to localise cause for oncogenic osteomalacia (OOM). Materials and Methods: Retrospective analysis between March 2015 to March 2018 of all patients with a clinical diagnosis (based on a combination of clinical history, hypophosphatemia and elevated FGF-23 values) of OOM who underwent Ga-68 DOTATATE PET/CT. Results: Total of 27 patients had undergone Ga-68 DOTATATE PET/CT imaging in our centre from March 2015 to March 2018. Of these 16 patients with clinically suspected oncogenic osteomalacia were included in our study. Age range 18-61 years of which 12 were males. Total of 13 (81.25%) patients were found to be positive on imaging for a possible mesenchymal tumour. Most common site of tumour was the lower limb (76%). Most common presenting symptom was bone pain (81%) followed by muscle weakness (19%). Overall, 10 patients underwent surgery, all of whose biopsy was reported as phosphaturic mesenchymal tumour. During the three month follow up, serum phosphorous measured in 15/16, post-surgical/ medical treatment had normalised in all except two patients who had undergone only medical therapy with neutral phosphate. Fall in FGF-23 was more pronounced in surgically treated patients as compared to those who received medical treatment. Conclusion: Ga68-DOTATE PET/CT is a useful investigatory modality for localizing cause for oncogenic osteomalacia.


How to cite this article:
John JR, Hephzibah J, Oommen R, Shanthly N, Mathew D. Ga-68 DOTATATE positron emission tomography-computed tomography imaging in oncogenic osteomalacia: Experience from a Tertiary Level Hospital in South India.Indian J Nucl Med 2019;34:188-193


How to cite this URL:
John JR, Hephzibah J, Oommen R, Shanthly N, Mathew D. Ga-68 DOTATATE positron emission tomography-computed tomography imaging in oncogenic osteomalacia: Experience from a Tertiary Level Hospital in South India. Indian J Nucl Med [serial online] 2019 [cited 2019 Aug 23 ];34:188-193
Available from: http://www.ijnm.in/article.asp?issn=0972-3919;year=2019;volume=34;issue=3;spage=188;epage=193;aulast=John;type=0