Indian Journal of Nuclear Medicine

: 2016  |  Volume : 31  |  Issue : 1  |  Page : 39--41

Intramedullary osteosclerosis of right femur confirmed on triphasic bone SPECT/CT in a patient with equivocal radiological features

Ameya D Puranik1, Natasha Singh1, Shailendra Maheshwari2, Nitin Gupta1, Pravin Wali2,  
1 Department of Nuclear Medicine and PET Imaging, P.D. Hinduja National Hospital and Medical Research Center, Mumbai, Maharashtra
2 Department of Radiology, P.D. Hinduja National Hospital and Medical Research Center, Mumbai, Maharashtra

Correspondence Address:
Ameya D Puranik
Department of Nuclear Medicine and PET Imaging, P.D. Hinduja National Hospital and Medical Research Center, Mumbai, Maharashtra


Sclerotic bone dysplasias are diagnosed based on clinical and radiological features; however, in some instances pose a dilemma. We herewith report a case of a 38-year-old female who presented with right lower extremity pain, and was detected to have sclerotic diaphyseal lesion on X-ray. Triphasic 99mTc methylene diphosphonate (MDP) Bone scan helped in confirming the diagnosis of intramedullary osteosclerosis, a dysplastic bone disorder.

How to cite this article:
Puranik AD, Singh N, Maheshwari S, Gupta N, Wali P. Intramedullary osteosclerosis of right femur confirmed on triphasic bone SPECT/CT in a patient with equivocal radiological features.Indian J Nucl Med 2016;31:39-41

How to cite this URL:
Puranik AD, Singh N, Maheshwari S, Gupta N, Wali P. Intramedullary osteosclerosis of right femur confirmed on triphasic bone SPECT/CT in a patient with equivocal radiological features. Indian J Nucl Med [serial online] 2016 [cited 2020 May 28 ];31:39-41
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Full Text


Sclerotic focal diaphyseal lesions in patients with painful lower limb are routinely evaluated using conventional X-ray imaging. However, radiological features pose a diagnostic dilemma. Triphasic bone scan in our case ruled out common clinical scenarios narrowing the diagnosis to sclerotic dysplasia. This helped in arriving at the diagnosis of intramedullary osteosclerosis (IMOS), with further correlation of clinical and pathological findings.


A 38-year-old female presented with complaints of pain in right thigh since 3 months, which gradually increased in intensity. Patient was on anti-inflammatory medications that provided transient pain relief with on and off bouts of pain and difficulty in walking. There was no history of trauma or family history of skeletal disorders. The patient was asymptomatic otherwise. Leukocyte count (5400/mm 3 ), erythrocyte sedimentation rate (15 mm/h), and alkaline phosphatase levels (61 IU/L) were within normal limits. Radiograph (X-ray) of right thigh [Figure 1]a and b, arrows, arrows showed diffuse diaphyseal sclerosis with widening of bone and endosteal hyperostosis. The patient was referred for whole body 99mTc-methylene diphosphonate (MDP) bone scan. Triphasic study was performed. Initial vascular phase and blood pool images at 2 min showed no evidence of increased vascularity or soft tissue tracer pooling [Figure 2]a-d. Delayed anterior and posterior planar images showed fusiform-shaped intense area of tracer uptake in the diaphysis of right femur [Figure 3]a-d, arrows, corresponding to the site of pain; with similar pattern of tracer localization of lesser intensity in left proximal femoral shaft [Figure 3]c and d, arrowheads. No abnormal tracer uptake was seen in rest of the skeletal system. Fused single photon emission computed tomography/computed tomography (SPECT/CT) images showed tracer localized to intense sclerosis in the intra-medullary region with associated overlying cortical thickening in bilateral femoral diaphysis [Figure 4]a-c, right - triangulate, left - arrow, visualized more prominently on right side. CT-guided biopsy was performed. Pathological findings of replacement of normal spongiosa by sclerotic trabeculae devoid of osteocytes with associated degeneration were seen. Since there was no similar family history, correlation of clinical, imaging, and pathological findings yielded the diagnosis of intra-medullary osteosclerosis. The patient was referred for medullary reaming, since pain was not relived by analgesics, and follow-up is awaited.{Figure 1}{Figure 2}{Figure 3}{Figure 4}


Sclerotic intramedullary lesions on radiographs in patients with painful long bones have a number of differentials such as malignancy (osteosarcoma, lymphoma), infections (osteomyelitis), trauma (stress fracture), or bone dysplasias. Absence of increased vascularity on initial flow images of triphasic bone scan was suggestive of low probability for malignancy, infection and stress fracture. Furthermore, findings of increased tracer uptake predominantly in the medullary cavity and in the thickened cortex, confined to both femoral diaphysis, raised a high possibility of dysplastic bone disorder. Comprehensive analysis of clinical, pathological, and imaging findings helped us confirming the diagnosis of IMOS. IMOS was first described by Abdul-Karim et al[1] in 1988, as an unusual pathological condition characterized by endosteal new bone formation and sclerosis in diaphysis of long bones in adults. It has a higher predominance in women, especially affecting at middle age. [2] Clinically IMOS involves lower extremities, commonly tibia followed by femur, and presents as chronic severe pain unrelieved by non-steroidal anti-inflammatory drugs. Few cases have been reported in literature so far; [3],[4],[5] with the last one highlighting the role of bone scan. Isolated radiological findings are not diagnostic; hence, the role of triphasic bone scan in ruling out other differentials is valuable. Even then, similar pattern on radiograph and bone scan has been observed in other congenital developmental skeletal dysplasias such as Ribbing disease [6] or Camurati-Engelmann disease. [7] Histologically, Camurati-Engelmann disease demonstrates both osteoclastic and blastic activity, unlike IMOS. [8] However, Ribbing disease and IMOS share the same histological features, hence were close differentials. [9] As in our patient, there was no positive family history, hence Ribbing disease, which is an autosomal recessive inherited disorder, was ruled out. Radiological features in skeletal dysplasias are not pathognomonic of this condition, and triphasic bone scan helps narrow down the differentials. Thus, this case highlights the role of bone scan and demonstrates its imaging features in IMOS. It also underlines the importance of correlating clinical and histological features with imaging findings for accurate diagnosis in bone dysplasias like IMOS, which thereby impacts further management. [10]

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