Indian Journal of Nuclear Medicine

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 26  |  Issue : 3  |  Page : 131--134

Fourier phase analysis on equilibrium gated radionuclide ventriculography: Range of phase spread and cut-off limits in normal individuals


Vijayaraghavan L Ramaiah, B Harish, HV Sunil, Job Selvakumar, AG Ravi Kishore, Gopinathan Nair 
 Department of Nuclear Medicine and Department of Cardiology, Narayana Hrudayalaya Institute of Medical Sciences, Bengaluru, Karnataka, India

Correspondence Address:
Vijayaraghavan L Ramaiah
No 258A, Bommasandra Industrial Area, Narayana Health City, Anekal Taluk, Hosur Road, Bangalore 560099, Karnataka
India

Aim: To define the range of phase spread on equilibrium gated radionuclide ventriculography (ERNV) in normal individuals and derive the cut-off limit for the parameters to detect cardiac dyssynchrony. Materials and Methods: ERNV was carried out in 30 individuals (age 53±23 years, 25 males and 5 females) who had no history of cardiovascular disease. They all had normal left ventricular ejection fraction (LVEF 55-70%) as determined by echocardiography, were in sinus rhythm, with normal QRS duration (≤120 msec) and normal coronary angiography. First harmonic phase analysis was performed on scintigraphic data acquired in best septal view. Left and right ventricular standard deviation (LVSD and RVSD, respectively) and interventricular mechanical delay (IVMD), the absolute difference of mean phase angles of right and left ventricle, were computed and expressed in milliseconds. Mean + 3 standard deviation (SD) was used to derive the cut-off limits. Results: Average LVEF and duration of cardiac cycle in the study group were 62.5%±5.44% and 868.9±114.5 msec, respectively. The observations of LVSD, RVSD and right and left ventricular mean phase angles were shown to be normally distributed by Shapiro-Wilk test. Cut-off limits for LVSD, RVSD and IVMD were calculated to be 80 msec, 85 msec and 75 msec, respectively. Conclusion: Fourier phase analysis on ERNV is an effective tool for the evaluation of synchronicity of cardiac contraction. The cut-off limits of parameters of dyssynchrony can be used to separate heart failure patients with cardiac dyssynchrony from those without. ERNV can be used to select patients for cardiac resynchronization therapy.


How to cite this article:
Ramaiah VL, Harish B, Sunil H V, Selvakumar J, Ravi Kishore A G, Nair G. Fourier phase analysis on equilibrium gated radionuclide ventriculography: Range of phase spread and cut-off limits in normal individuals.Indian J Nucl Med 2011;26:131-134


How to cite this URL:
Ramaiah VL, Harish B, Sunil H V, Selvakumar J, Ravi Kishore A G, Nair G. Fourier phase analysis on equilibrium gated radionuclide ventriculography: Range of phase spread and cut-off limits in normal individuals. Indian J Nucl Med [serial online] 2011 [cited 2020 Sep 22 ];26:131-134
Available from: http://www.ijnm.in/article.asp?issn=0972-3919;year=2011;volume=26;issue=3;spage=131;epage=134;aulast=Ramaiah;type=0