Indian Journal of Nuclear Medicine

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 26  |  Issue : 2  |  Page : 67--77

Spectrum of neurocognitive dysfunction in Indian population on FDG PET/CT imaging


Rajnish Sharma1, Madhavi Tripathi1, Maria M D'Souza1, Abhinav Jaimini1, Raunak Varshney2, Puja Panwar2, Aruna Kaushik2, Sanjeev Saw1, Romana Seher1, Santosh Pandey1, Dinesh Singh1, Yachna Solanki1, Anil K Mishra2, Anupam Mondal1, RP Tripathi1 
1 Division of Pet Imaging, Molecular Imaging Research Center, INMAS, Delhi, India
2 Division of Cyclotron and Radiopharmaceutical Sciences, Molecular Imaging Research Center, INMAS, Delhi, India

Correspondence Address:
Rajnish Sharma
Division of PET Imaging, Molecular Imaging Research Center, INMAS, Lucknow Road, Timarpur, Delhi-110 054
India

Background : A variety of neurodegenerative disorders produce significant abnormal brain function which can be detected using fluorodeoxyglucose positron emission tomography (FDG PET) scan even when structural changes are not detected on CT or MRI Scan. A study was undertaken at our institute to evaluate the FDG PET/CT findings in Indian population suffering from mild cognitive impairment (MCI), Alzheimer«SQ»s disease (AD), fronto-temporal dementia (FTD), dementia with lewy body disease (DLBD) and other miscellaneous causes of dementia. Materials and Methods : 117 0 subjects having neurocognitive deficits and 36 normals were included in our study. All patients underwent a detailed history and clinical examination. This was followed by a mini mental state examination. Subsequently an FDG brain PET scan and an MRI were done. Results :In the patient population included in our study group 36 were normal, 39 had MCI, 40 had AD, 14 had FTD, and 13 had DLBD and 11 dementia due to other miscellaneous causes. MCI patients showed primarily reduced tracer uptake in the mesio-temporal cortex. AD patients showed reduced tracer concentration in temporo-parietal lobes, while patients with advanced diseases showed frontal lobe disease additionally. In subjects of FTD, reduced radiotracer uptake in the fronto-temporal lobes was noted. In addition, FTD patients also showed basal ganglia defects. In contrast the DLBD patients showed globally reduced FDG uptake including severely affecting the occipital cortices. Conclusion :In the current study the F18-FDG PET scans have been shown to be highly useful in the diagnosis of various neurocognitive disorders of the brain. AD was found to be the most common dementia in the Indian population followed by MCI. Diffuse Lewy body disease, FTD and other miscellaneous categories of dementia had a near similar incidence.


How to cite this article:
Sharma R, Tripathi M, D'Souza MM, Jaimini A, Varshney R, Panwar P, Kaushik A, Saw S, Seher R, Pandey S, Singh D, Solanki Y, Mishra AK, Mondal A, Tripathi R P. Spectrum of neurocognitive dysfunction in Indian population on FDG PET/CT imaging.Indian J Nucl Med 2011;26:67-77


How to cite this URL:
Sharma R, Tripathi M, D'Souza MM, Jaimini A, Varshney R, Panwar P, Kaushik A, Saw S, Seher R, Pandey S, Singh D, Solanki Y, Mishra AK, Mondal A, Tripathi R P. Spectrum of neurocognitive dysfunction in Indian population on FDG PET/CT imaging. Indian J Nucl Med [serial online] 2011 [cited 2019 Oct 22 ];26:67-77
Available from: http://www.ijnm.in/article.asp?issn=0972-3919;year=2011;volume=26;issue=2;spage=67;epage=77;aulast=Sharma;type=0