Indian Journal of Nuclear Medicine
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Year : 2019  |  Volume : 34  |  Issue : 2  |  Page : 173-175

Immune checkpoint inhibitors (Nivolumab)-induced enterocolitis demonstrated on 18Fluorine-fluorodeoxyglucose positron emission tomography-computed tomography


1 Department of Nuclear Medicine, Kuwait Cancer Control Center, Khaitan; Jaber Al-Ahmad Molecular Imaging Center, Kuwait City, Kuwait
2 Department of Nuclear Medicine, Kuwait Cancer Control Center, Khaitan, Kuwait
3 Jaber Al-Ahmad Molecular Imaging Center, Kuwait City, Kuwait

Correspondence Address:
Dr. Sharjeel Usmani
Department of Nuclear Medicine, Kuwait Cancer Control Center, P. O. Box: 1488, Khaitan 83001
Kuwait
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnm.IJNM_141_18

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Nivolumab, an immune checkpoint inhibitor, is a humanized anti-programmed death-1 monoclonal antibody that is used for the treatment of various cancers after second-line chemotherapy. We report a 23-year-old male with relapsed Hodgkin's lymphoma Stage IV treated with nivolumab. After 3 months of treatment, he developed watery diarrhea and cramping abdominal pain. Follow-up positron emission tomography-computed tomography scan showed complete metabolic resolution of the disease; however, there is bowel wall thickening and colonic distension with corresponding increased fluorodeoxyglucose uptake. These findings are related to immune-related adverse event associated with nivolumab treatment, i.e., secondary enterocolitis. These adverse events can be successfully treated if timely and appropriately diagnosed.


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