|Year : 2019 | Volume
| Issue : 2 | Page : 143-146
Osteoid osteoma of distal fibula: A rare location and its management
Saurav Narayan Nanda1, Kanhaiyalal Agrawal2, Sandeep Velagada1, Sujit Kumar Tripathy1
1 Department of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar Odisha, India
2 Department of Nuclear Medicine, All India Institute of Medical Sciences, Bhubaneswar Odisha, India
|Date of Web Publication||8-Apr-2019|
Dr. Kanhaiyalal Agrawal
Department of Nuclear Medicine, All India Institute of Medical Sciences, SIJUA, Bhubaneswar - 751 019, Odisha
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Osteoid osteoma (OO) of distal fibula is extremely rare, and only few cases are reported in the literature. We report a case of OO of distal fibula and its surgical management at our tertiary care hospital.
Keywords: Bone scan, long bones, osteoid osteoma, single photon emission computed tomography-computed tomography, three-dimensional
|How to cite this article:|
Nanda SN, Agrawal K, Velagada S, Tripathy SK. Osteoid osteoma of distal fibula: A rare location and its management. Indian J Nucl Med 2019;34:143-6
|How to cite this URL:|
Nanda SN, Agrawal K, Velagada S, Tripathy SK. Osteoid osteoma of distal fibula: A rare location and its management. Indian J Nucl Med [serial online] 2019 [cited 2019 Dec 16];34:143-6. Available from: http://www.ijnm.in/text.asp?2019/34/2/143/255601
| Introduction|| |
Osteoid osteoma (OO) is an uncommon bone tumor accounting for 10% of all symptomatic bone tumors and 5% of overall primary bone tumors., Jaffe was first to describe this completely benign bone tumor as a distinct entity. Reports of spontaneous conversion of OO to osteoblastoma have proved to be mere misdiagnosis. OO is most commonly seen in adolescents and young adults with male predilection of 2–3:1.,
OO is typically small lesions, 1.5–2 cm in size, fairly common in long bones with 50%–60% of cases occurring in proximal femur and mid-diaphysis of tibia. The second-most common site is the spine accounting for 7%–20% of cases with predominance in posterior elements. There have been reports of OO occurring in almost all bones including cranium and face. The distal fibula is very uncommon site, and to our knowledge, only one case has been reported earlier. In distal fibula OO, the patient generally presents with ankle pain, swelling, and difficulty in walking not relieved by ordinary analgesics. We here report a case of OO of distal fibula diagnosed with the help of plain radiography, computed tomography (CT) scan, bone single photon emission CT-CT (SPECT-CT), and further managed.
| Case Report|| |
A 38-year-old male patient, businessman by profession, presented to the outpatient department with a chief complaint of diffuse and continuous pain in the left ankle and difficulty in walking since the past 6 months. The pain was more on lateral aspect of ankle and more in the night time. There was no history of trauma, fever, loss of weight, and loss of appetite. He was taking tablet aspirin orally as when required, which helped him to get relief from pain. On examination, there was local tenderness and mild swelling at the anterolateral aspect of ankle. Ankle movement was full with dorsiflexion terminally painful. On radiological examination, X-ray showed osteosclerotic lesion around a central lucent area suspicious of OO with nidus in the medial aspect of distal fibula at the level of ankle joint [Figure 1]. CT scan showed the nidus with surrounding reactive sclerosis in the left distal fibula [Figure 2]. Three phase bone scan and SPECT-CT using Technetium-99m (Tc-99m) methylene diphosphonate were also done. Three phase bone scan showed increased tracer accumulation in the left ankle joint [Figure 3]. However, the increased tracer uptake was diffuse heterogeneous in pattern and was not specific to OO. Therefore, SPECT-CT was performed, which localizes most focal uptake to a sclerotic lesion with central nidus in the left distal fibula anteromedially [Figure 4] and [Figure 5]. The lower grade diffuse uptake localized to the ankle joint, likely due to articular changes because of pain. This confirmed the diagnosis of OO in the left distal fibula.
|Figure 1: Plain radiograph of left ankle joint shows lucency in the medial margin of the distal fibula with surrounding sclerosis, likely to be osteoid osteoma. There is a bone island in the distal left tibia|
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|Figure 2: Cross-section of computed tomography scan shows lucency (arrow) suggestive of nidus with surrounding sclerosis|
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|Figure 3: Three phase Tc-99m methylene diphosphonate bone scan (anterior view) shows diffuse heterogeneous tracer uptake in the left ankle in all three phases (flow, blood pool, and delayed) of bone scan|
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|Figure 4: Single photon emission computed tomography-computed tomography of the left ankle (intensity adjusted) localizes most prominent tracer uptake (arrow in c and d) to a lucency with mild sclerotic rim (arrow in a and b) in the left distal fibula anteromedially, confirming osteoid osteoma|
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|Figure 5: Three-dimensional single photon emission computed tomography-computed tomography fusion image clearly localizes the most prominent uptake to the anteromedial surface of the left fibula adjacent to the inferior tibiofibular articulation|
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We decided to perform an open procedure using anterolateral approach to excise the lesion along with the reactive bone, sparing the syndesmosis, and articular cartilage. The patient was placed in supine position with a sandbag under the affected side buttock under regional anesthesia with pneumatic tourniquet at the thigh. A longitudinal incision of 5 cm was given at the anterior border of fibula the ankle joint, and distal fibula was exposed. The nidus location was identified by reactive cortical bone area of about 0.5 cm × 0.5 cm and further confirmed by fluoroscopy. The lesion was excised and sent for histopathology study. Adequate care was taken to prevent injury to syndesmosis joint and articular cartilage of fibula.
Postoperatively, the patient was comfortable, and the earlier specific type of continuous pain was disappeared except for surgical site pain which was reducing gradually. The patient was advised for full weight bearing mobilization. At 2 weeks, stitches were removed, and at that time the patient was absolutely pain free. Postoperative X-ray showed complete excision the lesion. Histopathological examination confirmed the diagnosis of OO of distal fibula. The patient was followed up at 1, 3, and 6 months' postsurgery and there was no evidence of any recurrence.
| Discussion|| |
Patients with OO are usually younger and rarely present after 30 years of age. Approximately half of the all cases present between 10 and 20 years of age. It predominantly affects long bone and spine.,, According to a location within bone, they are further subdivided into cortical which is most common, cancellous and subperiosteal variants which may be intracapsular and subcapsular.
Histologically, it is characterized by a vascular nidus of osteoid and woven bone surrounded by dense sclerotic reactive bone. The nidus has a high concentration of COX1 and COX2 enzymes which leads to high levels of prostaglandin (PGE) production particularly PGE2. PGE2 leads to pain, vasodilatation, inflammation, and reactive bone formation.
The usual clinical presentation is pain which is related to PGE production. Pain predominates at night and rapidly responds to nonsteroidal anti-inflammatory drugs. Another possible explanation of pain is the rich nerve supply within the nidus similar to glomus tumor. If the tumor is intracapsular, it can mimic nonspecific arthritis/synovitis which can lead to delay in diagnosis.
The diagnosis is usually made with plain X-ray, being accurate in 75% of cases. OO is characterized by a radiolucent nidus surrounded by a dense rim of sclerotic bone. This feature is typical of cortical OO, whereas cancellous and subperiosteal variants have minimal reactive bone formation and may not be clearly visible in plain radiograph. Further, the nidus is not always visible on radiographs in OO of small bones and spine. CT scan still remains the gold standard for the diagnosis of OO and it clearly defines the nidus and the sclerotic extension. Hyperintensity in T2-weighted images of magnetic resonance imaging (MRI) due to intramedullary edema may misdiagnosed an OO to a malignant/aggressive bone tumor. Hence, MRI plays a questionable role in diagnosis. Three-phase bone scan is useful when an OO is suspected, but radiography is not diagnostic or when symptoms are atypical. The typical picture in three-phase bone scan is focal increased radiotracer uptake in the OO in all three phases of scan. Three-phase bone scan has excellent sensitivity for the diagnosis of OO. However, it has limited specificity. SPECT-CT combines the metabolic and anatomical information in a single study and increases the specificity of the three-phase planar bone scan. In the present case, also the planar bone scan was not characteristic of an OO; however, SPECT-CT confirmed the diagnosis on radionuclide scan.
Classic surgical en bloc resection remains the most common modality of treatment which in some studies has shown almost no recurrence but carries an inherent risk of iatrogenic fracture. CT-guided radiofrequency ablation has shown promising results with a recurrence rate of 5%–10%. Radiofrequency ablation, although a minimally invasive technique and cosmetically pleasing to the patient, carries a high risk of thermal injury to the spinal cord or neurovascular bundle when the lesion is in its proximity and hence not always feasible.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]