Indian Journal of Nuclear Medicine
Home | About IJNM | Search | Current Issue | Past Issues | Instructions | Ahead of Print | Online submissionLogin 
Indian Journal of Nuclear Medicine
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 36790 Print this page  Email this page Small font size Default font size Increase font size


 
 Table of Contents     
LETTER TO THE EDITOR
Year : 2018  |  Volume : 33  |  Issue : 3  |  Page : 266  

Role of preablative-stimulated thyroglobulin in prediction of nodal and distant metastasis on iodine whole-body scan


Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Date of Web Publication11-Jun-2018

Correspondence Address:
Sapana Bothra
Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnm.IJNM_46_18

Rights and Permissions

How to cite this article:
Bothra S, Mayilvaganan S. Role of preablative-stimulated thyroglobulin in prediction of nodal and distant metastasis on iodine whole-body scan. Indian J Nucl Med 2018;33:266

How to cite this URL:
Bothra S, Mayilvaganan S. Role of preablative-stimulated thyroglobulin in prediction of nodal and distant metastasis on iodine whole-body scan. Indian J Nucl Med [serial online] 2018 [cited 2020 Aug 8];33:266. Available from: http://www.ijnm.in/text.asp?2018/33/3/266/234134



Sir,

We read with interest the article “Role of Preablative-Stimulated Thyroglobulin in Prediction of Nodal and Distant Metastasis on Iodine Whole-Body Scan” by Prabhu et al.[1] We would like to congratulate the authors on their experience of preablative-stimulated thyroglobulin in reliably excluding metastatic disease in differentiated thyroid cancer (DTC). We would agree with this finding of ps-Tg value in the absence of anti-Tg antibodies <1 ng/ml excluding metastasis and helping in tailoring radioiodine ablation routinely with ps-Tg >5 mg/ml and individualizing ps-Tg between 1 and 5 mg/ml. One of the most important factors in the management of DTC is the management of central neck nodes. As it is said the surgical battle of DTC is won or lost in the central comportment. The central compartment lymph node dissection (CCLND) in DTC has a crucial role, especially in prognosis and also recurrence.[2],[3],[4] Reoperative thyroid surgeries are fraught with increased incidence of recurrent laryngeal nerve injury and hypoparathyroidism. We have few queries which may interest future readers.

Did the authors perform CCLND (prophylactic and therapeutic) and what proportion of these patients had recurrence? Did any of the patients have foci of poorly differentiated carcinoma? How many patients had metastasis at the time of presentation? Did any of these patients have Contrast Enhanced computed tomography scan as preoperative imaging? Did any of these patients have raising Tg level with no finding on iodine whole-body scan which necessitated positron-emission tomography scan?

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Prabhu M, Samson S, Reddy A, Venkataramanarao SH, Chandrasekhar NH, Pillai V, et al. Role of preablative stimulated thyroglobulin in prediction of nodal and distant metastasis on iodine whole-body scan. Indian J Nucl Med 2018;33:93-8.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Lang BH, Wong KP, Wan KY, Lo CY. Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma. Ann Surg Oncol 2012;19:60-7.  Back to cited text no. 2
    
3.
Wang TS, Evans DB, Fareau GG, Carroll T, Yen TW. Effect of prophylactic central compartment neck dissection on serum thyroglobulin and recommendations for adjuvant radioactive iodine in patients with differentiated thyroid cancer. Ann Surg Oncol 2012;19:4217-22.  Back to cited text no. 3
    
4.
Wang TS, Cheung K, Farrokhyar F, Roman SA, Sosa JA. A meta-analysis of the effect of prophylactic central compartment neck dissection on locoregional recurrence rates in patients with papillary thyroid cancer. Ann Surg Oncol 2013;20:3477-83.  Back to cited text no. 4
    




 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References

 Article Access Statistics
    Viewed227    
    Printed1    
    Emailed0    
    PDF Downloaded73    
    Comments [Add]    

Recommend this journal