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Year : 2015  |  Volume : 30  |  Issue : 4  |  Page : 350-351  

Flip-flop phenomenon in systemic sclerosis on fluorodeoxyglucose positron emission tomography/computed tomography


1 Department of Nuclear Medicine, Marmara University, School of Medicine, Istanbul, Turkey
2 Department of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

Date of Web Publication1-Sep-2015

Correspondence Address:
Kevser Oksuzoglu
Marmara University Pendik Research and Application Hospital, Nuclear Medicine Department, Floor -1, Fevzi Cakmak Neighborhood Muhsin Yazicioglu Street Number: 10, Ust Kaynarca, Pendik, Istanbul
Turkey
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Source of Support: Nil., Conflict of Interest: None declared.


DOI: 10.4103/0972-3919.164018

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   Abstract 

Systemic sclerosis (SSc) is a rare autoimmune disease, which may affect multiple organ systems. Fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) can demonstrate the degree and anatomical extent of involvement in the entire body and coexisting malignancies in connective tissue diseases. We present a case of SSc with an increased 18F-FDG uptake in the cutaneous and subcutaneous tissues even higher than the neighboring skeletal muscles ("flip-flop phenomenon," that is, an increased 18F-FDG uptake in the skin but a decreased 18F-FDG uptake in the skeletal muscles).

Keywords: Fluorine-18-fluorodeoxyglucose, positron emission tomography/computed tomography, systemic sclerosis


How to cite this article:
Oksuzoglu K, Ozen G, Inanir S, Direskeneli RH. Flip-flop phenomenon in systemic sclerosis on fluorodeoxyglucose positron emission tomography/computed tomography. Indian J Nucl Med 2015;30:350-1

How to cite this URL:
Oksuzoglu K, Ozen G, Inanir S, Direskeneli RH. Flip-flop phenomenon in systemic sclerosis on fluorodeoxyglucose positron emission tomography/computed tomography. Indian J Nucl Med [serial online] 2015 [cited 2019 Dec 15];30:350-1. Available from: http://www.ijnm.in/text.asp?2015/30/4/350/164018

A 55-year-old male was presented with digital ulcers, exertional dyspnea intermittent attacks of diarrhea. He was diagnosed as systemic sclerosis (SSc) with the findings of the 1-year duration of Raynaud phenomenon, typical fibrotic skin changes, anti-nuclear antibody = 1/320, and anti-Scl-70 positivity. He had bibasilar rales, and initial thorax high-resolution computed tomography (CT) evaluation of the chest revealed bilateral ground glass attenuation along with an 8 mm spiculated nodule at the right middle lobe of the lung in the ex-smoker patient. Positron emission tomography/CT (PET/CT) was performed for excluding coexisting malignancy. Fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT demonstrated rarely seen diffuse skin uptake that was interpreted as a technical artifact at the initial scan and the scan was repeated 2 days later. There was no pathological 18F-FDG uptake in the lung nodule. A mild 18F-FDG uptake (SUVmax: 2.8) was seen in the lung lesions suggestive for infection/inflammation [Figure 1]a. Interestingly, an increased 18F-FDG uptake arrows, (SUVmax: 1.1) even higher than the neighboring skeletal muscles was observed in the cutaneous and subcutaneous tissues, which were prominently revealed in gluteal region [[Figure 1]b, arrows]. After the exclusion of malignancy while he was planned to receive cyclophosphamide, intestinal pseudo-obstruction, persistent attacks of bradycardia, and asystole were developed. The patient died despite all supportive measures, 1-month after diagnosis of SSc.
Figure 1: (a) Maximum intensity projection reconstruction of CT attenuation-corrected PET image data shows diffuse increased skin FDG uptake. (b) Mild FDG uptake in the inflammatory lung lesions and increased FDG uptake in the cutaneous and subcutaneous tissue higher than the neighbouring skeletal muscles are seen.

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Fluorine-18-fluorodeoxyglucose PET/CT demonstrated skin involvement and interstitial lung disease and excluded coexisting malignancy in this patient. 18F-FDG PET/CT is a promising imaging modality for detecting coexistent neoplastic disease and other autoimmune disorders.[1] The associated neoplasms with SSc include breast and lung cancer.[2],[3] Many causes of cutaneous 18F-FDG uptake have been described before in various malignant disorders including malignant melanoma, skin lymphomas, and Kaposi sarcoma, etc.[4],[5] It has been also reported in benign tumors or lesions such as psoriasis, cutaneous and subcutaneous sarcoidosis, Sweet syndrome, etc.[6],[7],[8] However, cutaneous 18F-FDG uptake has not yet been reported in SSc with skin involvement. In this patient with diffuse SSc, flip-flop phenomenon (i.e., an increased 18F-FDG uptake in the skin but a decreased 18F-FDG uptake in the skeletal muscles) can be explained by the thickening of cutaneous tissue and muscle atrophy. Extracellular matrix overproduction by activated fibroblasts and interactions among endothelial and inflammatory cells may be responsible for the observed hypermetabolism in the skin.

 
   References Top

1.
Nishiyama Y, Yamamoto Y, Dobashi H, Kameda T. Clinical value of 18F-fluorodeoxyglucose positron emission tomography in patients with connective tissue disease. Jpn J Radiol 2010;28:405-13.  Back to cited text no. 1
    
2.
Lu TY, Hill CL, Pontifex EK, Roberts-Thomson PJ. Breast cancer and systemic sclerosis: A clinical description of 21 patients in a population-based cohort study. Rheumatol Int 2008;28:895-9.  Back to cited text no. 2
    
3.
Peters-Golden M, Wise RA, Hochberg M, Stevens MB, Wigley FM. Incidence of lung cancer in systemic sclerosis. J Rheumatol 1985;12:1136-9.  Back to cited text no. 3
    
4.
Sheng Y, Chen L, Huang Z, Mu Z, Kong J, Luo Y, et al. Granulomatous slack skin: Assessment of disease progression and treatment response using positron emission tomography/computed tomography. Clin Lymphoma Myeloma 2009;9:455-8.  Back to cited text no. 4
    
5.
Morooka M, Ito K, Kubota K, Yanagisawa K, Teruya K, Hasuo K, et al. Usefulness of F-18 FDG PET/CT in a case of Kaposi sarcoma with an unexpected bone lesion. Clin Nucl Med 2011;36:231-4.  Back to cited text no. 5
    
6.
Bruna-Muraille C, Pochart JM, Papathanassiou D, Guedec-Ghelfi R, Cuif-Job A, Liehn JC. Incidental finding of F-18 FDG skin uptake in a patient with psoriasis during the evaluation of a recurrent papillary thyroid carcinoma. Clin Nucl Med 2011;36:34-5.  Back to cited text no. 6
    
7.
Li Y, Berenji GR. Cutaneous sarcoidosis evaluated by FDG PET. Clin Nucl Med 2011;36:584-6.  Back to cited text no. 7
    
8.
Dong A, Wang Y, Gao L, Zuo C. 18F-FDG PET/CT findings in a patient with Sweet syndrome associated with myelodysplastic syndrome. Clin Nucl Med 2013;38:e454-7.  Back to cited text no. 8
    


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