Indian Journal of Nuclear Medicine
Home | About IJNM | Search | Current Issue | Past Issues | Instructions | Ahead of Print | Online submissionLogin 
Indian Journal of Nuclear Medicine
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 196 Print this page  Email this page Small font size Default font size Increase font size
CASE REPORT
Year : 2014  |  Volume : 29  |  Issue : 1  |  Page : 34-37

Paradoxal metabolic flare detected by 18F-fluorodeoxyglucose positron emission tomography in a patient with metastatic breast cancer treated with aromatase inhibitor and biphosphonate


1 Department of Diagnostic PET, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
2 Department of Radiotherapy, Centre of Oncology, Maria Skłodowska-Curie Memorial Institute, Cracow, Poland

Correspondence Address:
Andrea D'Amico
Department of Diagnostic PET, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Ul Wybrzeże AK 15, 44-101 Gliwice
Poland
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.125769

Rights and Permissions

Patients with estrogen-receptor-positive advanced breast cancer are treated with endocrine therapy. The majority of breast cancer localizations show 18F-fluorodeoxyglucose (FDG) uptake at positron emission tomography (PET) examination. In these patients, the metabolic flare after therapy is common and was proposed as an index of therapy efficacy. Nevertheless, prolonged persistence of flare can lead to misinterpretation. We describe a case of a patient with invasive ductal breast cancer with bone metastases at bone scintigraphy and FDG PET scan and with expression of estrogen receptors. Initially, the patient underwent endocrine therapy in addition to a biphosfonate. Owing to progression observed in a bone scan, Tamoxifen was substituted with aromatase inhibitors. Successive bone scan examinations showed stabilization with a marked clinical improvement. A second FDG PET was performed 28 months after the first examination and showed a metabolic flare phenomenon with concomitant partial calcification of osteolitic lesions. This is an unusual case of prolonged metabolic flare.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1179    
    Printed38    
    Emailed0    
    PDF Downloaded38    
    Comments [Add]    
    Cited by others 1    

Recommend this journal