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ORIGINAL ARTICLE
Year : 2013  |  Volume : 28  |  Issue : 4  |  Page : 207-209  

Indigenously developed close delivery system for oral iodine-131 therapy: Nominal cost but phenomenal protection


1 Department of Nuclear Medicine, Dr. Ziauddin Medical University Hospital, Karachi, Pakistan
2 Department of Radiology, Section of Nuclear Medicine, Aga Khan University Hospital (AKUH), Karachi, Pakistan
3 Department of Nuclear Cardiology, Karachi Institute of Heart Diseases (KIHD), Karachi, Pakistan

Date of Web Publication25-Nov-2013

Correspondence Address:
Maseeh uz Zaman
Department of Radiology, Section of Nuclear Medicine, Aga Khan University Hospital, Karachi - 74800
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.121964

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   Abstract 

Background: Administration of radiopharmaceuticals through intravenous and oral routes is the major source of radiation exposure to nuclear medicine (NM) technologists. Adopting new strategies to minimize radiation exposure is an important step toward safe practice in nuclear pharmacy. Materials and Methods: We have indigenously developed a relatively close delivery system for oral administration of radioiodine-131 ( 131 I) to minimize radiation exposure to the technologists. Results: The efficacy of this indigenously developed close system was assessed upon 23 patients who were given 131 I therapies for benign (13 patients) and malignant thyroid disorders (10 patients). There was 64 ± 6% (P < 0.05) reduction in exposure rate using indigenously developed delivery system. Conclusion: The cost involved in developing this system was very nominal, but efficacy in terms of radiation safety and confidence of our technologists were phenomenal.

Keywords: Indigenous system, nuclear medicine technologist, radiation exposure, radioioidine-131 therapy


How to cite this article:
Fatima N, uz Zaman M, Shah IA, Ul Haq I, Javed A. Indigenously developed close delivery system for oral iodine-131 therapy: Nominal cost but phenomenal protection. Indian J Nucl Med 2013;28:207-9

How to cite this URL:
Fatima N, uz Zaman M, Shah IA, Ul Haq I, Javed A. Indigenously developed close delivery system for oral iodine-131 therapy: Nominal cost but phenomenal protection. Indian J Nucl Med [serial online] 2013 [cited 2019 Nov 14];28:207-9. Available from: http://www.ijnm.in/text.asp?2013/28/4/207/121964


   Introduction Top


In nuclear medicine (NM) department, technologists are exposed to ionizing radiation in nuclear pharmacy while preparing and administering the radiopharmaceutical, in imaging room and also in handling the patients after the completion of procedures. In a fairly busy NM department, the average radiation dose received by a technologist was below 5 milliSievert (mSv) and about 60% of dose was received during injecting radiopharmaceuticals to the patients. [1] This is well below the annual dose limit of 20 mSv for radiation workers. [2] In recent days, there has been an increase use of radioiodien-131 ( 131 I) for thyroid disorders [3] and also 131 I labeled targeted radionuclide therapy for nonthyroidal cancers. For thyroid disorders, 131 I is administered orally and for other target radionuclide therapies, an intravenous infusion is usually used. These procedures carry a potential risk of significant exposure to NM staff and physicians despite of adopting well-known strategies of time, distance, and shielding. In most of NM departments in Pakistan, 131 I is administered orally in a liquid form by the technologists and in our department patients were used to give liquid 131 I in a disposable glass to drink. This indeed was a source of significant but avoidable source of radiation exposure to our technologists. Recently, we have designed an indigenous reasonably close delivery system for oral administration of 131 I to patients with toxic goiters and well-differentiated thyroid cancers.


   Materials and Methods Top


We used a thick lead container in which 131 I vial is supplied and transported by the vendor. With the help of our biomedical division, the lumen of the thick lead vial container was broadened to accommodate a disposable plastic glass to be filled with liquid 131 I. A small circular hole was also made in the center of cap (cover) of lead vial container to insert a disposable straw to drink liquid 131 I. To minimize radiation exposure from straw while patient is taking 131 I, we have used a long cylindrical lead covering to house this straw. This lead cylinder to shield a straw was made from 1 mm thick semicircular lead linings around hot column of an expired 99 Molybdenum- 99m Technetium generator [Figure 1].
Figure 1: (a) Disposable glass and straw without lead shield for 131I treatment previously used; (b) Indigenously designed close delivery system with widened cavity of lead vial and an opening in top cover to insert a straw and; (c) Lead shielded straw and heavily shielded vial with liquid 131I

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To assess the efficiency of this indigenous, relatively close delivery system, we measured exposure rates at 1 m distance at patient's torso level using a survey meter (VICTOREEN, Model no: 450, USA) with and without said system for various strength of 131 I. It was tested in first 23 patients who were referred for iodine treatment to our department for benign and malignant thyroid disorders. This was a small prospective study conducted from April 2013 till 15 th July 2013 at Nuclear Medicine Department of Dr. Ziauddin Medical University, Karachi, Pakistan.

Statistical analysis

Data were analyzed by using commercially available packages the Medcalc® statistical software version 11.3.10 and statistical package for social sciences (SPSS version 17® ). A two-tailed student's t-test was used to compare continuous variables. Bland-Altman's plot was used to see the difference of exposure rates with and without lead with mean values. P < 0.05 was considered significant.


   Results Top


We tested this system upon first 23 patients (17 females and 6 males with a mean age of 49 ± 14 years). 131 I therapy was administered for benign thyroid diseases in 13, while 10 patients had well-differentiated thyroid cancers. The average administered dose of 131 I for benign disease was 555 ± 148 MBq (15 ± 4 mCi) and for malignant conditions it was 5032 ± 1443 MBq (136 ± 39 mCi). Average measured exposure in milliRoentgen/hour (mR/h) at 1 m distance without lead vial was 5.416 ± 3.423 and with lead it was 1.903 ± 1.254 [Table 1]. The difference between exposures rates with and without lead was analyzed by Bland-Altman's curve which revealed all the differences were close to the mean line and no significant outlier was noted [Figure 2]. The percentage reduction in exposure rate by using lead system was 64 ± 6% [t-test: −4.687, P < 0.05] [Figure 3].
Figure 2: Bland-Altman's scatter plot of exposure rate difference with and without using lead container for radioactive iodine oral administration

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Figure 3: Comparative analysis of exposure rate during oral administration of radioactive iodine with and without using lead container

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Table 1: Patients' demographic

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   Discussion Top


In recent years, overwhelming use of radiation-based diagnostic and therapeutic procedures has been noticed. This has indeed been responsible for reported exorbitant radiation exposure to people [4] and also a matter of serious concern for radiation workers. The annual radiation exposure of our technologists has always been well below the statutory limits. But due to significant rise in referral of radioiodine therapies to our center since March 2013, we were skeptical about an increase in radiation exposure to our technologists. Following the As low as reasonable achievable (ALARA) principle, we considered to acquire commercially available close system for 131 I delivery. However, cost of such system was significantly high. This cost limitation had initiated the idea of developing this system indigenously. The measured values of exposure rates have shown efficacy of this close system in minimizing the radiation exposure to our technologists. In Bland-Altman's curve with fall of measured values close to the mean value also rules out outlier and reproducibility of the measuring methodology. Literature search has revealed a close vacuum-assisted system designed for administration of high doses of 131 I by Prabhakar et al., India. [5] No data regarding radiation exposure with and without vacuum-assisted system were presented. In last few years, two important studies have pointed out increased incidence of brain tumor in interventional cardiologist [6] and higher incidence of cancer in offspring of radiation workers. [7] These data are indeed alarming for radiation workers, but adopting every effort to minimize radiation exposures like developing indigenous close delivery system and its validity by on-site measurement improves their confidence. The cost involved in developing this system was very nominal, but efficacy in terms of radiation safety and confidence of our technologists were phenomenal.

 
   References Top

1.Lundberg TM, Gray PJ, Bartlett ML. Measuring and minimizing the radiation dose to nuclear medicine technologists. J Nucl Med Technol 2002;30:25-30.  Back to cited text no. 1
[PUBMED]    
2.National Council on Radiation Protection and Measurements. Ionizing radiation exposure of the population of the United States: Recommendation of the National Council on Radiation Protection and Measurements. Report No. 160, Bethesda, MD: NCRP; 2009.  Back to cited text no. 2
    
3.Edwards BK, Howe HL, Ries LA, Thun MJ, Rosenberg HM, Yancik R, et al. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden. Cancer 2002;94:2766-92.  Back to cited text no. 3
    
4.Einstein AJ, Weiner SD, Bernheim A, Kulon M, Bokhari S, Johnson LL, et al. Multiple testing, cumulative radiation dose, and clinical indications in patients undergoing myocardial perfusion imaging. JAMA 2010;304:2137-44.  Back to cited text no. 4
[PUBMED]    
5.Rao VP, Sudhakar P, Swamy VK, Pradeep G, Venugopa N. Closed system vacuum assisted administration of high dose radio iodine to cancer thyroid patients: NIMS technique. Indian J Nucl Med 2010;25:34-5.  Back to cited text no. 5
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6.Roguin A, Goldstein J, Bar O. Brain tumours among interventional cardiologists: A cause for alarm? Report of four new cases from two cities and a review of the literature. Euro Intervention 2012;7:1081-6.  Back to cited text no. 6
[PUBMED]    
7.Johnson KJ, Alexander BH, Doody MM, Sigurdson AJ, Linet MS, Spector LG, et al. Childhood cancer in the offspring born in 1921-1984 to US radiologic technologists. Br J Cancer 2008;99:545-50.  Back to cited text no. 7
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