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ORIGINAL ARTICLE
Year : 2013  |  Volume : 28  |  Issue : 4  |  Page : 200-206

Quality control of positron emission tomography radiopharmaceuticals: An institutional experience


Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India

Correspondence Address:
Jaya Shukla
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.121963

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Purpose of the Study: To study quality control parameters of routinely prepared positron emission tomography (PET) radiopharmaceuticals. Materials and Methods: Three PET radiopharmaceuticals fluorine-18 fluorodeoxyglucose (F-18 FDG), N-13 ammonia (N-13 NH 3 ), and Ga-68 DOTATATE (n = 25 each), prepared by standardized protocols were used. The radionuclide purity, radiochemical purity, residual solvents, pH, endotoxins, and sterility of these radiopharmaceuticals were determined. Results: The physical half-life of radionuclide in radiopharmaceuticals, determined by both graphical and formula method, demonstrated purity of radionuclides used. pH of all PET radiopharmaceuticals used was in the range of 5-6.5. No microbial growth was observed in radiopharmaceutical preparations. The residual solvents, chemical impurity, and pyrogens were within the permissible limits. Conclusions: All three PET radiopharmaceuticals were safe for intravenous administration.


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