Indian Journal of Nuclear Medicine
Home | About IJNM | Search | Current Issue | Past Issues | Instructions | Ahead of Print | Online submissionLogin 
Indian Journal of Nuclear Medicine
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 50 Print this page  Email this page Small font size Default font size Increase font size


 
 Table of Contents     
CASE REPORT
Year : 2013  |  Volume : 28  |  Issue : 2  |  Page : 99-101  

Hepatic metastasis disguised as fat spared area in the background of fatty liver: Detection on FDG PET/CT


Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India

Date of Web Publication16-Sep-2013

Correspondence Address:
Venkatesh Rangarajan
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai - 400 012, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.118263

Rights and Permissions
   Abstract 

Area of fat sparing in fatty liver is known to pose a diagnostic challenge in an oncological setting, especially in cancers with higher propensity for liver metastases. We report an unusual appearance of hepatic metastases in a fat spared area, on both computed tomography (CT) and positron emission tomography (PET), in a combined 18 fluorine-fluorodeoxyglucose (18 F-FDG) PET/CT study done in metastatic adenocarcinoma of colon.

Keywords: Computed tomography, fat sparing, fatty liver, FDG PET


How to cite this article:
Puranik AD, Purandare NC, Agrawal A, Shah S, Rangarajan V. Hepatic metastasis disguised as fat spared area in the background of fatty liver: Detection on FDG PET/CT. Indian J Nucl Med 2013;28:99-101

How to cite this URL:
Puranik AD, Purandare NC, Agrawal A, Shah S, Rangarajan V. Hepatic metastasis disguised as fat spared area in the background of fatty liver: Detection on FDG PET/CT. Indian J Nucl Med [serial online] 2013 [cited 2019 Dec 11];28:99-101. Available from: http://www.ijnm.in/text.asp?2013/28/2/99/118263


   Introduction Top


Heterogenous nature of FDG uptake often poses a challenge in picking up diffuse metastatic disease, more so, when associated with fatty liver. We report a case of metastatic liver disease which apparently appeared normal, in background of fatty liver.


   Case Report Top


A 65-year-old gentleman was diagnosed with carcinoma of sigmoid colon 2 years back, for which he underwent sigmoid colectomy. Histopathological analysis revealed moderately differentiated adenocarcinoma. Patient then received adjuvant chemotherapy. Serial carcino-embryogenic antigen (CEA) levels and follow-up imaging were normal until 1 year, when metastatic lesion was seen in segment VII of liver. Patient underwent transarterial chemo-embolization (TACE) and radiofrequency ablation (RFA), which led to complete regression of liver lesion. Follow-up was uneventful for 6 months, after which a rising trend was seen in CEA levels. Whole body 18 F - FDG PET/CT study was done. Maximum intensity projection (MIP) image showed diffuse tracer uptake in left side of liver [Figure 1] - arrow] and a focus of abdominal uptake [[Figure 1]- arrowhead] in midline. Axial venous phase CT images showed fatty infiltration in entire right lobe of liver [Figure 2]a - thick arrow], with associated post-treatment changes at the site of treated liver lesion. Left branch of portal vein was patent, with no evidence of tumor infiltration. Axial fused PET/CT image showed no tracer uptake in the right lobe. Diffuse pattern of intense tracer uptake was seen in a wedge shaped area in the left lobe of the liver [Figure 2]b - arrow] which, however, showed normal enhancement on CT images [Figure 2]a - arrow]. Maximum standardized uptake value (SUV max in g/ml) was 17.3. No focal hypodense lesion was seen. Midline abdominal uptake corresponded to the abdominal wall metastatic nodule [Figure 2]c and d - arrow]. Though FDG uptake pattern in liver favored metastasis in the background of rising CEA, the anatomical picture was not supportive. Hence, CT guided biopsy was performed, which was confirmatory for metastases from adenocarcinoma. Patient was started on alternative chemotherapy regimen, and follow-up PET/CT was done in 3 months. MIP images showed persistent hypermetabolism in the left lobe metastases [[Figure 3] - arrow], with mild reduction seen in metabolic activity of abdominal wall deposit [Figure 3] - arrowhead]. Axial CT and fused PET/CT images showed no change in metabolic activity and extent of metastatic site in the left lobe of liver, max SUV being 16.7 [Figure 4]a, b - arrows]. There was a mild reduction in metabolic activity of abdominal wall nodule, with size remaining unchanged, as seen on the axial CT [Figure 4]c - arrow] and fused PET/CT [Figure 4]d - arrow] images. In view of stable disease, with no new metastatic site, patient is being planned for left hepatectomy and abdominal nodule excision [Event chronology - [Table 1].
Figure 1: Maximum intensity projection image showing diffuse hepatic tracer uptake (arrow) with focal uptake (arrow-head) corresponding to abdominal wall nodule

Click here to view
Figure 2: (a) Axial computed tomography (CT) image showing large area of fatty liver (thick arrow) with normally enhancing rest of the liver (arrow), (b) Fused axial positron emission tomography (PET)/CT image showing diffuse tracer uptake (arrow) in the area with normal enhancement on CT (a - arrow). Axial CT (c - arrow) and fused PET/CT images (d - arrow) showing ill-defined anterior abdominal wall nodule showing fluorodeoxyglucose uptake

Click here to view
Figure 3: Post-treatment status, maximum intensity projection image showing persistent diffuse fluorodeoxyglucose uptake in the left lobe of liver (arrow) with a mild reduction in tracer uptake in abdominal wall nodule (arrow-head, compared to Figure 1)

Click here to view
Figure 4: Axial CT (a) and fused PET/CT (b) images showing no change in size, metabolic activity, and enhancement pattern in metastatic lesion in the left lobe of liver (arrows), compared to Figure 2a and b. Axial CT (a) and fused PET/CT (b) images shows ill-defined nodule in anterior abdominal wall, showing a mild reduction in metabolic activity, with no change in size, compared to Figure 2c and d

Click here to view
Table 1: Chronology of disease - investigations done

Click here to view



   Discussion Top


Focal fat sparing in the presence of diffuse fatty liver is most commonly seen around the gall bladder fossa and appears as a spot or band on cross-sectional imaging. [1] However, it can also occur in other parts of the liver and in various shapes, such as a wedge shaped area, as seen in our case. [2] These patterns have been reported to mimic metastases on cross-sectional imaging. [3],[4] Contrarily, a true hepatic lesions simulate fat sparing, is documented in a single case, where US and magnetic resonance imaging (MRI) was used for confirmation. [5] Fatty liver is seen as diffuse hypodensity on CT images, with attenuation values less than 40 Hounsfield units (HU) on unenhanced images. [6] As a result, there is an apparent hyper-attenuation in the fat spared region of liver. Similar finding was seen on the CT component of PET/CT images in our case. Also, intense tracer uptake seen in the fat spared area. However, the interesting fact was the pattern of FDG uptake - diffuse with involvement of entire left lobe with no focality. This was quite unlike, a metastatic liver lesion, [7] more so when the previous metastatic site in segment VII, which was subsequently treated, showed a characteristic rounded appearance. Both these findings - apparent hyper-attenuation on CT in absence of focality and diffuse homogenous tracer uptake pattern on PET in the fat spared area of liver, when seen together can be a misleading, and metastatic lesion can be 'missed'. The clinching factor here is the intensity of FDG uptake, depicted by SUV max value, which was high in our case. Since such a high grade of FDG uptake is characteristic of adenocarcinoma metastases, [8] the lesion most likely favored metastatic involvement. This was subsequently confirmed on histology and follow up PET/CT study. Such pattern of liver morphology and metabolism in the presence of fatty liver, is a "red herring" on FDG PET/CT imaging and needs to be kept in mind. Correlation with tumor histology and intensity of radiotracer concentration serve as useful tools in reaching proper diagnosis in these cases.

 
   References Top

1.Chen K, Hiramatsu Y, Yunoki M, Hirano Y. Focal sparing around the gallbladder in fatty liver: An useful sign in the diagnosis of borderline cases by CT. Nihon Igaku Hoshasen Gakkai Zasshi 1989;49:146-52.  Back to cited text no. 1
[PUBMED]    
2.Mitchell DG. Focal manifestations of diffuse liver disease at MR imaging. Radiology 1992;185:1-11.  Back to cited text no. 2
[PUBMED]    
3.Kissin CM, Bellamy EA, Cosgrove DO, Slack N, Husband JE. Focal sparing in fatty infiltration of the liver. Br J Radiol 1986;59:25-8.  Back to cited text no. 3
[PUBMED]    
4.Purandare NC, Rangarajan V, Rajnish A, Shah S, Arora A, Pathak S. Focal fat spared area in the liver masquerading as hepatic metastasis on F-18 FDG PET imaging. Clin Nucl Med 2008;33:802-5.  Back to cited text no. 4
[PUBMED]    
5.Onaya H, Itai Y, Kurosaki Y, Saida Y, Ebihara R, Kuramoto K. Metastatic tumors in irregular fatty liver mimicking focal sparing. Radiat Med 1994;12:69-73.  Back to cited text no. 5
[PUBMED]    
6.Boyce CJ, Pickhardt PJ, Kim DH, Taylor AJ, Winter TC, Bruce RJ, et al. Hepatic steatosis (fatty liver disease) in asymptomatic adults identified by unenhanced low-dose CT. AJR Am J Roentgenol 2010;194:623-8.  Back to cited text no. 6
[PUBMED]    
7.Delbeke D, Martin WH, Sandler MP, Chapman WC, Wright JK Jr, Pinson CW. Evaluation of benign vs malignant hepatic lesions with positron emission tomography. Arch Surg 1998;133:510-5.  Back to cited text no. 7
[PUBMED]    
8.Sahani DV, Kalva SP, Fischman AJ, Kadavigere R, Blake M, Hahn PF, et al. Detection of liver metastases from adenocarcinoma of the colon and pancreas: Comparison of mangafodipir trisodium-enhanced liver MRI and whole-body FDG PET. AJR Am J Roentgenol 2005;185:239-46.  Back to cited text no. 8
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]
 
 
    Tables

  [Table 1]



 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed1281    
    Printed32    
    Emailed0    
    PDF Downloaded51    
    Comments [Add]    

Recommend this journal