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LETTER TO EDITOR
Year : 2012  |  Volume : 27  |  Issue : 4  |  Page : 272-273  

Hyperostosis fronto-parietalis mimicking metastasis to the skull: Unveiled on SPECT/CT


Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

Date of Web Publication23-Jul-2013

Correspondence Address:
Nishikant A Damle
Department of Nuclear Medicine and PET, All India Institute of Medical Sciences, New Delhi - 110 029
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.115406

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How to cite this article:
Tripathi M, Bal C, Damle NA, Singhal A. Hyperostosis fronto-parietalis mimicking metastasis to the skull: Unveiled on SPECT/CT. Indian J Nucl Med 2012;27:272-3

How to cite this URL:
Tripathi M, Bal C, Damle NA, Singhal A. Hyperostosis fronto-parietalis mimicking metastasis to the skull: Unveiled on SPECT/CT. Indian J Nucl Med [serial online] 2012 [cited 2019 May 23];27:272-3. Available from: http://www.ijnm.in/text.asp?2012/27/4/272/115406

A 65-year post-menopausal female, treated case of right breast carcinoma had chest wall recurrence and was sent for bone scintigraphy to rule out skeletal involvement. The planar bone scan revealed heterogeneously increased tracer uptake involving bilateral frontal and parietal bones [Figure 1]a and b. The remaining skeleton showed normal tracer distribution. To characterize this lesion SPECT/CT of the cranium was carried out. It revealed nodular and irregular thickening of the inner table of the frontal bone extending to involve the parietal bones [Figure 2]. The midline was spared and the external surface of the skull was unaffected, which is characteristic of hyperostosis fronto-parietalis. Thus the heterogeneous pattern of Tc-99m Methylene diphosphonate uptake could be attributed to hyperostosis ruling out the possibility of sclerotic metastasis. The importance of recognizing this entity on bone scans stems mainly from the necessity of not mistaking it for metastasis.
Figure 1: 99mTc-methylene diphosphonate planar bone scan revealed heterogeneously increased tracer uptake involving bilateral frontal and parietal bones. The remaining skeleton showed normal tracer distribution

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Figure 2: SPECT/CT of the cranium was done on Symbia T6 SPECT/ CT (Siemens). Transaxial fused SPECT/CT images revealed irregular thickening and nodularity of the inner table of bilateral frontal and parietal bones showing increased tracer accumulation

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Hyperostosis frontalis interna (HFI) has been reported in 5-12% of the general population, [1] but is more commonly seen in women. [2] HFI is characterized by benign overgrowth of the inner table of the frontal bone. It is seen most commonly in older, post-menopausal females. Its etiology is as yet unknown. Hypotheses suggested involve the role of leptin, a peptide that helps to control the metabolic rate. [3] Men with hormonal irregularities, such as those with atrophic testes, have been seen to have HFI of variable severity. [4] The condition is generally of no clinical significance and an incidental finding, but sometimes the growth can be exuberant and cause compression of brain tissue. [5] Our patient also had no history of neurological disorders or headache. HFI is typically bilateral symmetrical and may extend to involve parietal bones. Moore classified HFI under the broad category of metabolic craniopathy, which also included, nebula frontalis, hyperostosis calvaria diffusa, and hyperostosis frontoparietalis, named according to the location of the lesion. [6] The skull thickening may be sessile or nodular and may affect the skull in a focal or diffuse manner. The importance of this condition stems mainly from the necessity of no mistaking it for a malignant pathology.

 
   References Top

1.Jaffe HL. Metabolic, degenerative, and inflammatory disease of bones and joints. London: Henry Kimptom Pub; London; 1972. p. 272-7.  Back to cited text no. 1
    
2.Gershon-Cohen J, Schraer H, BlumbERG N. Hyperostosis frontalis interna among the aged. Am J Roentgenol Radium Ther Nucl Med 1955;73:396-7.  Back to cited text no. 2
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3.Rühli FJ, Henneberg M. Are hyperostosis frontalis interna and leptin linked? A hypothetical approach about hormonal influence on human microevolution. Med Hypotheses 2002;58:378-81.  Back to cited text no. 3
    
4.Hershkovitz I, Greenwald C, Rothschild BM, Latimer B, Dutour O, Jellema LM, et al. Hyperostosis frontalis interna: An anthropological perspective. Am J Phys Anthropol 1999;109:303-25.  Back to cited text no. 4
[PUBMED]    
5.Chaljub G, Johnson RF 3 rd , Johnson RF Jr, Sitton CW. Unusually exuberant hyperostosis frontalis interna: MRI. Neuroradiology 1999;41:44-5.  Back to cited text no. 5
    
6.Moore MT. Metabolic craniopathy. Am J Roentgenol 1944;35:30-9.  Back to cited text no. 6
    


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