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LETTER TO EDITOR
Year : 2012  |  Volume : 27  |  Issue : 2  |  Page : 136-137  

Assessment of early response to treatment in extrapulmonary tuberculosis: Role of FDG-PET


Department of Nephrology and Nuclear Medicine, SVIMS, Tirupati, India

Date of Web Publication18-Apr-2013

Correspondence Address:
Manjusha Yadla
SVIMS, Tirupati, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.110712

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How to cite this article:
Yadla M, Sivakumar V, Kalawat T. Assessment of early response to treatment in extrapulmonary tuberculosis: Role of FDG-PET. Indian J Nucl Med 2012;27:136-7

How to cite this URL:
Yadla M, Sivakumar V, Kalawat T. Assessment of early response to treatment in extrapulmonary tuberculosis: Role of FDG-PET. Indian J Nucl Med [serial online] 2012 [cited 2020 Jan 27];27:136-7. Available from: http://www.ijnm.in/text.asp?2012/27/2/136/110712

Sir,

We report an elderly man on dialysis who was evaluated for a suspected bronchogenic carcinoma with fluorodeoxyglucose positron emission tomography (FDG-PET) computed tomography (CT) scan. His scan revealed multiple mediastinal lymph nodes and skeletal lesions [Figure 1] which were later confirmed to be tuberculosis (TB) on TB PCR, Lowenstein-Jensen medium. Three days after initiation of anti-tubercular therapy (ATT), metabolic activity in lymph nodes decreased significantly [Figure 2] though the skeletal lesion activity persisted. Three months after ATT, there was complete resolution of both lymph nodal and skeletal lesions [Figure 3]. Earliest response to ATT on FDG-PET CT was reported to be at the end of eight-week therapy. [1] FDG-PET/CT is the imaging modality that is useful in detecting extra-pulmonary TB and also in assessment of early response to ATT as early as 3 days.
Figure 1: Fluorodeoxyglucose-positron emission tomography computed tomography scan showing multiple cervical and mediastinal group of lymhnodes along with skeletal lesions

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Figure 2: Fluorodeoxyglucose-positron emission tomography computed tomography scan showing decreased tracer uptake in cervical and mediastinal lymphnodes, 3 days after initiation of anti-tubercular therapy

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Figure 3: Fluorodeoxyglucose-positron emission tomography computed tomography scan showing normal uptake of tracer in the lymphnodes

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   References Top

1.Harisankar C, Mittal BR, Bhattacharya A, Singh B. FDG-PET/CT in diagnosis and early response evaluation of extra-pulmonary tuberculosis in a patient with aplastic anemia. J Postgrad Med 2010;56:219-21.  Back to cited text no. 1
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  [Figure 1], [Figure 2], [Figure 3]



 

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