Indian Journal of Nuclear Medicine
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CASE REPORT
Year : 2011  |  Volume : 26  |  Issue : 4  |  Page : 188-191

Oncogenic osteomalacia diagnosed by blood pool scintigraphy


1 Department of Nuclear Medicine and PET/CT, Amrita Institute of Medical Sciences and Research Center, Cochin, Kerala, India
2 Department of Endocrinology, Amrita Institute of Medical Sciences and Research Center, Cochin, Kerala, India

Correspondence Address:
Shanmuga Sundaram Palaniswamy
Consultant and Head, Department of Nuclear Medicine and PET/CT, Amrita Institute of Medical Sciences and Research Centre, Cochin - 680 2041, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.106702

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Oncogenic osteomalacia is a rare metabolic bone disease characterized by phosphaturia and hypophosphatemia. Certain tumors secrete a phosphaturic factor, which results in this metabolic abnormality; this factor called as phosphatonin, is in fact a fibroblast growth factor 23 (FGF-23) involved closely in phosphate homeostasis and skeletogenesis. Complete excision of these tumors facilitates reversal of the problem. We have reported here the case of a patient who was crippled with this disease and on thorough investigation revealed an oncogenic osteomalacia with tumor focus in the right tibia. The tumor was identified as a mesenchymal tumor, i.e., hemangiopericytoma. Tumor excision alleviated patient symptoms with rapid symptomatic and biochemical improvement.


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