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ORIGINAL ARTICLE
Year : 2011  |  Volume : 26  |  Issue : 3  |  Page : 139-143

Comparative study of 18 F-DOPA, 13 N-Ammonia and F18-FDG PET/CT in primary brain tumors


Department of Nuclear Medicine and Neurosurgery, Army Hospital, Research and Referral, Delhi Cantt, New Delhi, India

Correspondence Address:
Mattakarottu J Jacob
Department of Nuclear Medicine, Army Hospital Research and Referral, Delhi Cantt, New Delhi-110 010
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.103996

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Aim: To determine the diagnostic reliability of 18 F-FDOPA, 13 N-Ammonia and F18-FDG PET/CT in primary brain tumors. We evaluated the amino acid and glucose metabolism of brain tumors by using PET with 18 F-FDOPA, 13 N-Ammonia and F18-FDG PET/CT. Materials and Methods : Nine patients undergoing evaluation for brain tumors were studied. Tracer uptake was quantified by the use of standardized uptake values and the ratio of tumor uptake to normal identical area of contra lateral hemisphere (T/N). In addition, PET uptake with 18 F-FDOPA was quantified by use of ratio of tumor uptake to striatum uptake (T/S). The results were correlated with the patient's clinical profile. Results : Both high-grade and low-grade tumors were well visualized with 18 F-FDOPA. The sensitivity for identifying tumors was substantially higher with 18 F-FDOPA PET than with F18-FDG and 13 N-Ammonia PET as determined by simple visual inspection. The sensitivity for identifying recurrence in low grade gliomas is higher with 13 N-Ammonia than with F18-FDG. Conclusion: 18 F-FDOPA PET is more reliable than F18-FDG and 13 N-Ammonia PET for evaluating brain tumors.


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