Indian Journal of Nuclear Medicine
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CASE REPORT
Year : 2011  |  Volume : 26  |  Issue : 2  |  Page : 104-106

Transformation of myelodysplastic syndrome to acute myeloid leukemia: A case with whole-body 2-[F18] fluoro-2-deoxy-d-glucose positron emission tomography


1 Cancer Center, Nanfang Hospital, Southern Medical University, Guangzhou, China
2 Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Correspondence Address:
Qinghua Cao
Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou-510080
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.90264

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The case reported here was that of an old woman characterized by pancytopenia, chromosome clonal abnormality, fluctuation of the percent of blast cells at 20%, and negative evidence of malignancy in whole-body 2-[F18] fluoro-2-deoxy-d-glucose positron emission tomography (F18-FDG PET). After about 10 months, the blast cells accounted for about 25%, the morphology of which was similar to that of previous ones, and F18-FDG PET demonstrated diffusing increased uptake in the right upper leg and lymph nodes and patchy high uptake of bone marrow. 2-[F18]-fluoro-2-deoxyglucose can reflect extramedullary infiltration and bone marrow cellularity of the whole body, compared with invasive, regional biopsies and aspirations. The value of 2-[F18]-fluoro-2-deoxyglucose or 3'-deoxy-3'-[F18]-fluorothymidine positron emission tomography as an indicator in predicting the transformation of myelodysplastic syndrome to acute myeloid leukemia needs to be explored in the future.


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