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ORIGINAL ARTICLE
Year : 2010  |  Volume : 25  |  Issue : 2  |  Page : 49-52

Estimation of effective half life of clearance of radioactive Iodine ( 131 I) in patients treated for hyperthyroidism and carcinoma thyroid


1 Medical Physics Unit, National Oncology Center, Royal Hospital, Muscat-111, Oman
2 Department of Nuclear Medicine, National Oncology Center, Royal Hospital, Muscat-111, Oman

Correspondence Address:
R Ravichandran
Chief Medical Physicist, National Oncology Center, Royal Hospital, PB1331, PC111, Muscat
Oman
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-3919.72686

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Background : In medical applications of radioisotopes, for calculations of whole body doses and radiation safety applications, there is a need to estimate radioactive body burden. Local recommendations in Oman stipulate the need for hospitalization of patients treated for radioactive-iodine ( 131 I) with activities above 400 MBq. Materials & Methods: A study of body burden estimation from sequentially measured exposure rates from patients treated for carcinoma thyroid and hyperthyroidism was undertaken. A digital auto-ranging beta gamma survey instrument calibrated for measurement of exposure rates is used in this study. Results: The mean measured exposure rates at 1 m in μSv/h immediately after administration and at 24 h intervals are used for estimation of effective half time of clearance of administered activity. For patients with post-operative thyroid carcinoma, the variation of body burden with time post-administration indicated tri-exponential clearance pattern, with TŻeff values 14.4 h, 22 h, and 41.3 h. For patients treated for thyrotoxicosis, the body burden showed slow delayed clearance with a TŻeff - 111.4 h, and exposure rates did not show appreciable fall off after 48 h.


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