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ORIGINAL ARTICLE
Year : 2007  |  Volume : 22  |  Issue : 1  |  Page : 9-12

Preparation of 3-bromo-2,4,6-trimethyl HIDA and its 99m Tc-complex for hepatobiliary imaging


Radiopreparat Enterprise, Institute of Nuclear Physics, Academy of Sciences, 100214, pos, Ulugbek, Tashkent, Republic of Uzbekistan

Correspondence Address:
Kh Nurmatov
Institute of Nuclear Physics, Academy of Sciences, 100214, pos. Ulugbek, Tashkent, Republic of Uzbekistan

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Source of Support: None, Conflict of Interest: None


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3-bromo-(2,4,6-trimethylphenylcarbamoylmethyl) iminodiacetic acid (3-bromo-2,4,6-trimethyl HIDA) was synthesized, and lyophilized vials were prepared which contained 20 mg of 3-bromo-2,4,6-trimethyl HIDA and 0.4 mg of SnCl 2 . Radiochemical and biologic studies showed that this agent was obtained in high radiochemical purity, were stable in vitro and in vivo conditions. The compound, 99m Tc-3-bromo-2,4,6-trimethyl HIDA, possessed high hepatic specificity meaning that none of the tissues except for the hepatobiliary system showed radioactivity concentrations, and rapid hepatocellular transit and a rapid clearance from the blood circulation was observed. In conclusion, a lyophilized kit of HIDA and its labeling with 99m Tc can be applied as a hepatobiliary imaging agent for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct.


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