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REVIEW ARTICLE
Year : 2007  |  Volume : 22  |  Issue : 1  |  Page : 1-8

Pretargeting in radio bio-conjugate therapy: with reference to "rhenium, gold & lutetium as candidate therapy isotopes"


1 Nuclear Medicine & RIA unit P.G. Dept. of Medicine, S. N. Medical College, Agra, India
2 Department of Chemical Sciences, St. John's College, Agra, India

Correspondence Address:
D K Hazra
12/123, Nai Ki Mandi, Katra Hathi Shah, Agra
India
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Source of Support: None, Conflict of Interest: None


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Radiobioconjugate therapy is an emerging modality for Cancer in addition to conventional surgery, chemotherapy & external radio-therapy. The central problem of radio-bioconjugate therapy is the small fraction of radio-bioconjugate localized in the tumour. Pretargeting is one approach to maximize targeting in which an antibody construct, having a dual affinity both for tumour associated antigen as well as for a radio-labeled moiety is first administered followed by the radio-labeled moiety, which may be either biotin or a metal chelate. The relative merits of these are described & Rhenium-Re 186/188 , Gold-Au 199 & Lutetium-Lu 177 are suggested as candidate therapy isotopes in such pretargeting approaches.


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