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ORIGINAL ARTICLE
Year : 2006  |  Volume : 21  |  Issue : 1  |  Page : 12-17

Prevention of Radiation-Induced Clastogenic Effect by Diltiazem in Mouse Bone Marrow


Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India

Correspondence Address:
P K Goyal
Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004
India
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Source of Support: None, Conflict of Interest: None


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Intraperitoneal administration of diltiazem (DTZ), half an hour prior to whole-body gamma irradiation (5.0 Gy), showed the protection of animals from radiation-induced micronuclei in bone marrow. The frequency of micronuclei elevated from 6 to 24 hrs. post-irradiation in both irradiated groups but declined thereafter. The counts of micronuclei were found to be significantly lower in DTZ treated irradiated group and it restored to normal on 7th day, while the normal number of micronuclei observed in control group only after 28 days post-irradiation. These data demonstrate that DTZ protects mice bone marrow against radiationinduced micronucleus formation.


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